Project Description

Cycloastragenol (CAG)

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Basic information

Product name Cycloastragenol (CAG)  Other name Astramembrangenin, Cyclogalegigenin
Herb Source: Wild Astragalus membranaceus (Fisch.) Bge. / Mongolian Astragalus (Astragalus membranaceus var. mongholicus) Brand Name: Aniherb
Part: Dried Root Specification: 5%, 10%, 50%, 90%, 98% (HPLC-ELSD / HPLC-RID)
Active Ingredients Cycloastragenol Grade: Pharmaceutical, Food, Cosmetic Grade
Appearance:
  • 5%/10%: Brownish Yellow Powder
  • 50%/90%: Light Yellow Powder
  • 98%: White to Off-White Crystalline Powder
Extraction Type: Solvent Extraction + Biotransformation
Test Method: HPLC-ELSD / HPLC-RID Place of Origin: Shaanxi, China (Mainland)
Packaging: 1kg/aluminum foil bag, 25kg/fiber drum Certificate: ISO 9001, Halal, Kosher

Specifications

Cycloastragenol Test Method Appearance Herb Source
5% HPLC-ELSD Brownish Yellow Powder Wild Astragalus Root
10% HPLC-ELSD Brownish Yellow Powder Wild Astragalus Root
50% HPLC-ELSD Light Yellow Powder Wild Astragalus Root
90% HPLC-ELSD Light Yellow Powder Wild Astragalus Root
98% HPLC-ELSD White Crystalline Powder Wild Astragalus Root

What is Cycloastragenol (CAG)?

Cycloastragenol (CAG) is a tetracyclic triterpenoid sapogenin and the primary bioactive metabolite of Astragaloside IV, the signature compound of Astragalus root. Sourced from premium wild Astragalus membranaceus, it’s the only natural telomerase activator identified for dietary supplement and pharmaceutical use.
As a key longevity nutrient, CAG supports telomere maintenance, cellular rejuvenation, and age-related wellness. Backed by clinical research, it’s widely recognized for promoting healthy aging, cognitive function, and immune balance.

Biological Activity

Cycloastragenol stands out among natural triterpenoids for its multi-target cellular benefits:

Telomerase Activation: Stimulates telomerase to extend shortened telomeres, slowing cellular aging.
  • Antioxidant & Anti-Inflammatory: Scavenges free radicals, inhibits NLRP3 inflammasome, and reduces oxidative stress.
  • Neuroprotective: Supports neuron survival, enhances BDNF signaling, and improves cognitive function.
  • Cardioprotective: Improves endothelial function, regulates lipid metabolism, and supports heart health.
  • Bone & Joint Support: Reduces age-related bone loss and improves bone microarchitecture.

Key Benefits of Cycloastragenol

As a premium anti-aging and longevity ingredient, CAG offers science-backed benefits:

  • Supports Healthy Aging: Delays cellular senescence, promotes youthful vitality, and supports longevity.
  • Enhances Cognitive Function: Improves memory, focus, and mental clarity; supports brain health in aging adults.
  • Boosts Immune System: Strengthens immune defense, reduces inflammation, and supports immune balance.
  • Cardiovascular Wellness: Protects blood vessels, supports healthy cholesterol levels, and reduces heart disease risk.
  • Bone Health Support: Prevents osteoporosis, improves bone density, and supports joint flexibility.
  • Mood & Stress Relief: Regulates stress hormones, eases anxiety, and supports emotional balance.
  • Skin Rejuvenation: Promotes collagen synthesis, reduces wrinkles, and improves skin elasticity (cosmetic grade).
Applicable Crowd: Adults concerned about aging, middle-aged/elderly with memory decline, high-stress professionals, those seeking immune support, and individuals focusing on longevity and wellness.

Product Advantage

  • 5+ Years of R&D & Production: Specialized in Astragalus extract and CAG manufacturing with mature technology.
  • 100% Natural & Pure: Sourced from wild, pollution-free Astragalus roots; no synthetic additives or solvents.
  • High Purity & Stability: 98% CAG with strict HPLC quality control; low impurity profile ensures safety and efficacy.
  • Green Production: Adopts eco-friendly biotransformation (enzyme hydrolysis) and low-temperature extraction; no harmful solvent residues.
  • Custom Solutions: Offers multiple specifications (5%–98%) and tailored packaging for dietary supplements, cosmetics, and pharmaceuticals.
  • Global Compliance: Meets USP/EP standards; certified ISO 9001, Halal, Kosher for worldwide distribution.

Functions of Cycloastragenol

CAG’s functions are validated by extensive clinical and preclinical studies, making it a top choice for longevity and wellness formulations:
  1. Telomere & Cellular Rejuvenation: Activates telomerase to repair shortened telomeres, slowing cellular aging and extending healthy lifespan.
  2. Cognitive Enhancement: Improves learning, memory, and focus; supports brain health in neurodegenerative conditions.
  3. Immune Modulation: Enhances immune cell activity, reduces chronic inflammation, and strengthens resistance to infections.
  4. Cardiovascular Protection: Improves blood circulation, reduces oxidative damage to blood vessels, and supports heart function.
  5. Bone & Joint Health: Increases bone mineral density, reduces bone resorption, and relieves joint discomfort.
  6. Stress & Mood Regulation: Modulates cortisol levels, reduces anxiety and depression, and improves sleep quality.
  7. Skin Anti-Aging: Promotes collagen and elastin production, reduces fine lines and wrinkles, and brightens skin tone (cosmetic use).

Applications of Cycloastragenol

Softgel

Dietary Supplement Capsules/Tablets

Sports beverage

Functional Foods & Beverages

cosmetics lecithin

Cosmetics & Skincare Products

medical lecithin

Pharmaceutical Intermediates

Yogurt or milk

Health & Wellness Products

Production Process

  • Raw Material Selection: Premium dried roots of wild Astragalus membranaceus (harvested from Shaanxi/Gansu regions).
  • Extraction: Ethanol-water solvent extraction to obtain crude Astragalus extract rich in Astragaloside IV.
  • Biotransformation: Enzymatic hydrolysis (β-glucosidase/β-xylosidase) converts Astragaloside IV to Cycloastragenol.
  • Purification: Macroporous resin adsorption, silica gel column chromatography, and recrystallization for high-purity CAG.
  • Drying & Milling: Low-temperature vacuum drying and micronization to produce fine powder.
  • Quality Control: HPLC-ELSD testing for purity; heavy metal and microbial analysis for safety.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility
 Methanol  50.00  101.89  Soluble
 Ethanol  30.00  61.13  Soluble
 DMSO  66.67  135.86  Soluble (ultrasonic)
 Water  <0.10  <0.20  Practically Insoluble

Product Datasheets

Certificate of Analysis Certificate of Analysis Certificate of Analysis

COA of luteolin

Safety Datasheet

Safety Datasheet

Packing&Storage

  1. 1-5kg with double plastic container inside/aluminum foil bag outside. 10kg with double plastic container inside/carton outside. 25kg with double plastic container inside/fiber drum outside or it is at your option.
  2. Stored in a cool & dry well-closed container, keep away from moisture and strong light/heat.
  3. Shelf Life: Two years under well storage situation.

plant extract package

Transport&Payment

  • Small package sent by EMS, UPS, FedEx, DHL, etc.
  • Payment available for Western Union, T/T, Paypal, etc.
  • Cargo sent by Air or By Sea is all available.
    By Express By Air By Sea
    Suitable for under 50kg Suitable for more than 50kg Suitable for more than 500kg
    Delivery time: 4-5days Delivery time: 5-7days Delivery time: 15-30days
    Door to door service Airport to Airport Port to Port
    Easy to pick up the goods Professional broker needed Professional broker needed

     

Certifications