Project Description
Esculetin (CAS 305-01-1 )
Basic information
- Product Name: Esculetin, 6,7-Dihydroxycoumarin
- Alternative Names: Cichorigenin, Esculetine, Aesculetin
- Description:
- Chemical Names: 6,7-Dihydroxy-2H-1-Benzopyran-2-one; 6,7-Dihydroxycoumarin
- Purity:≥98% (HPLC), ≥99% (HPLC)
- Type of Compound: Natural Coumarin Derivative
- Physical Description: Off-white to Pale Yellow Crystalline Powder
- Herb source: Fraxinus chinensis, Artemisia capillaris, Cortex Mori, Bupleurum chinense
- Part Used: Bark, Leaf, Herb Aerial Part
Specifications
| M. Wt | 178.14 |
| Formula | C₉H₆O₄ |
| Storage | Sealed storage at 2-8°C, keep away from light and moisture |
| Purity | ≥98% / ≥99% (HPLC) |
| CAS Number | 305-01-1 |
| PubChem ID | 5281618 |
| InChI Key | XLYOFNOQVPJJNP-UHFFFAOYSA-N |
| Smiles | O=c1oc2cc(O)c(O)cc2c1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
What is Esculetin
Esculetin, also named 6,7-dihydroxycoumarin, is a natural bioactive coumarin compound widely extracted from traditional medicinal plants. It exists abundantly in ash bark, oriental wormwood, mulberry bark and other herbal materials. As a key secondary metabolite of plants, esculetin features stable chemical structure and remarkable biological activity. It serves as a core raw material widely applied in pharmaceutical intermediates, dietary supplements, cosmetic formulations and fine chemical industries, gaining extensive recognition for its natural origin and multiple physiological functions.
What are the benefits of Esculetin
- Powerful antioxidant capacity
Esculetin effectively scavenges free radicals in human body, inhibits oxidative damage to cells, delays skin aging and tissue degeneration, and protects normal cell vitality.
- Anti-inflammatory & analgesic effects
It suppresses excessive inflammatory factor secretion, relieves inflammatory swelling and pain symptoms, and assists in alleviating chronic inflammatory discomfort.
- Hypoglycemic and lipid-regulating properties
Esculetin helps regulate blood glucose and blood lipid level, improves lipid metabolism balance, and reduces risks of metabolic syndromes.
- Antibacterial and antiviral activity
It exerts obvious inhibitory effect on multiple harmful bacteria and viruses, enhancing body self-defense capability.
- Anti-tumor potential
Studies prove esculetin can restrain abnormal proliferation of tumor cells and induce cell apoptosis, presenting valuable anti-tumor research value.
- Skin protective efficacy
It inhibits melanin generation, fades pigment deposition, brightens skin tone and protects skin from ultraviolet damage.
Applications of Esculetin
- Pharmaceutical & pharmaceutical intermediate field
Esculetin is adopted as crucial raw material for synthesizing anti-inflammatory, hypoglycemic and anti-tumor drugs. It is used for developing prescriptions relieving joint inflammation, metabolic disorder and infectious symptoms, widely applied in modern pharmaceutical research and drug manufacturing.
- Health care & dietary supplement industry
As natural functional additive, esculetin is formulated into antioxidant, blood sugar regulating and lipid lowering supplements. It assists body metabolism adjustment, enhances immunity, reduces chronic disease risks, and meets daily health maintenance demands.
- Cosmetic & personal care field
Thanks to outstanding anti-oxidation, whitening and UV-resistant performance, esculetin is added into skin care creams, serums, lotions and sunscreen products. It diminishes dull complexion, reduces dark spots, alleviates skin redness, repairs damaged skin barrier and maintains healthy skin state.
- Food antioxidant & preservative field
It acts as natural food preservative and antioxidant, replacing synthetic preservatives to extend shelf life of beverages, snacks and meat products. It prevents food deterioration, retains original flavor and nutritional value with high safety.
- Fine chemical & biological research
Esculetin is commonly used as standard reference substance for plant component detection. It also works as research reagent for cell biology, pharmacology and natural product development, supporting laboratory analysis and new product exploitation.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM |
|---|---|---|
| Ethanol | 12.47 | 70 |
| DMSO | 17.81 | 100 |
| Methanol | 9.80 | 55 |
Product Datasheets
Packing&Storage
- 1-5kg with double plastic container inside/aluminum foil bag outside. 10kg with double plastic container inside/carton outside. 25kg with double plastic container inside/fiber drum outside or it is at your option.
- Stored in a cool & dry well-closed container, keep away from moisture and strong light/heat.
- Shelf Life: Two years under well storage situation.

Transport&Payment
- Small package sent by EMS, UPS, FedEx, DHL, etc.

- Payment available for Western Union, T/T, Paypal, etc.
- Cargo sent by Air or By Sea is all available.
By Express By Air By Sea Suitable for under 50kg Suitable for more than 50kg Suitable for more than 500kg Delivery time: 4-5days Delivery time: 5-7days Delivery time: 15-30days Door to door service Airport to Airport Port to Port Easy to pick up the goods Professional broker needed Professional broker needed
Certifications

